Zhang R, Su K, Yang L, et al. Design, synthesis, and biological evaluation of novel P2X7 receptor antagonists for the treatment of septic acute kidney injury. J Med Chem. 2023, 24;66(16):11365-11389. First author, CAS Q1 top journal, IF=6.8
Zhang R, Su K, Yang L, et al. Discovery of a Potent, Orally Active, and Long-Lasting P2X7 Receptor Antagonist as a Preclinical Candidate for Delaying the Progression of Chronic Kidney Disease. J Med Chem. 2024;67(19):17472-17496. First author, CAS Q1 top journal, IF=6.8
Zhang R, Rao Q, Jiang X, Ye N, et al. Exploring the Immunomodulatory Properties of Red Onion (Allium cepa L.) Skin: Isolation, Structural Elucidation, and Bioactivity Study of Novel Onion Chalcones Targeting the A2A Adenosine Receptor. J Agric Food Chem. 2023 Nov 6. First author, CAS Q1 top journal, IF=6.2
Zhang R, Li N, Zhao M, Tang M, et al. From lead to clinic: A review of the structural design of P2X7R antagonists. Eur J Med Chem. 2023, 5;251:115234. First author, CAS Q1 journal, IF=5.9
Zhang R, Hong F, Zhao M, et al. New highly potent NLRP3 inhibitors: furanochalcone velutone F analogues. ACS Med. Chem. Lett. 2022, 13(4):560-569. First author, CAS Q2 journal, IF=4.0
Li N, Zhang R, Tang M, et al. Recent Progress and Prospects of Small Molecules for NLRP3 Inflammasome Inhibition. J Med Chem. 2023, 9;66(21):14447-14473. Co-first author, CAS Q1 top journal, IF=6.8
Li N, Jiang X, Zhang R, Ye N, et al. Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis. J Med Chem. 2023, 12;66(19):13428-13451. Co-first author, CAS Q1 top journal, IF=6.8
Patents
Ye Haoyu, Ruijia Zhang, Su Kaiyue, Ma Liang; P2X7 receptor inhibitor; Patent No.: ZL 2022 1 0988191.1
Wu Wenshuang, Ruijia Zhang, Ye Haoyu; Natural chalcone derivative and its preparation method and use; Patent No.: ZL 2020 1 1584817.X
Ye Haoyu, Ruijia Zhang, Su Kaiyue, Ma Liang; Wu Wenshuang; P2X7R antagonist; International Application No.: PCT/CN2024/137672
Ye Haoyu, Ruijia Zhang, Su Kaiyue, Ma Liang, Wu Wenshuang; P2X7 receptor antagonist; Chinese Patent Publication No.: CN118184647A
